Multifocal micronodular pneumocyte hyperplasia (MMPH) is a subtype of
pneumocytic hyperplasia Pneumocytic hyperplasia is an hyperplasia of pneumocytes lining pulmonary alveoli.
Types
*Pulmonary atypical adenomatous hyperplasia Atypical adenomatous hyperplasia is a subtype of pneumocytic hyperplasia in the lung. It can be a precursor les ...
(hyperplasia of
pneumocytes lining
pulmonary alveoli
A pulmonary alveolus (plural: alveoli, from Latin ''alveolus'', "little cavity"), also known as an air sac or air space, is one of millions of hollow, distensible cup-shaped cavities in the lungs where oxygen is exchanged for carbon dioxide. A ...
).
Several synonymous terms have been done for this entity: adenomatoid proliferation of alveolar epithelium, papillary alveolar hamartoma, multifocal alveolar hyperplasia, multinodular pneumocyte hyperplasia.
These multifocal lesions are observed in
tuberous sclerosis
Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant genetic disease that causes non-cancerous tumours to grow in the brain and on other vital organs such as the kidneys, heart, liver, eyes, lungs and skin. A combination ...
, and can be associated with
lymphangioleiomyomatosis
Lymphangioleiomyomatosis (LAM) is a rare, progressive and systemic disease that typically results in cystic lung destruction. It predominantly affects women, especially during childbearing years. The term sporadic LAM is used for patients with LAM ...
and
perivascular epithelioid cell tumour
Perivascular epithelioid cell tumour, also known as PEComa or PEC tumour, is a family of mesenchymal tumours consisting of perivascular epithelioid cells (PECs). These are rare tumours that can occur in any part of the human body.
The cell type ...
(PEComa or clear cell "
sugar tumor")).
It can be diagnosed through
lung biopsy
A lung biopsy is an interventional procedure performed to diagnose lung pathology by obtaining a small piece of lung which is examined under a microscope. Beyond microscopic examination for cellular morphology and architecture, special stains and ...
using
thoracoscopy
Thoracoscopy is a medical procedure involving internal examination, biopsy and/or resection/drainage of disease or masses within the pleural cavity, usually with video assistance. Thoracoscopy may be performed either under general anaesthe ...
.
Microscopy
* Well-demarcated, nodular lesions ranging 2–5 mm in pulmonary parenchyma.
* Type II pneumocytes without nuclear atypia lined thickened alveolar septa and proliferated papillary structures.
* Enlarged cuboidal cells lining mildly thickened alveolar septa.
* Enlarged cuboidal cells have abundant, eosinophilic cytoplasm and large, round nuclei.
* Papillary pattern with irregular margin and lymphocyte infiltration in the stroma.
* No proliferation of immature smooth muscle cells suggestive of
lymphangioleiomyomatosis
Lymphangioleiomyomatosis (LAM) is a rare, progressive and systemic disease that typically results in cystic lung destruction. It predominantly affects women, especially during childbearing years. The term sporadic LAM is used for patients with LAM ...
.
See also
*
atypical adenomatous hyperplasia Atypical adenomatous hyperplasia is a subtype of pneumocytic hyperplasia in the lung. It can be a precursor lesion of in situ adenocarcinoma of the lung (bronchioloalveolar carcinoma).
In prostate tissue biopsy, it can be confused for adenocarci ...
*
pneumocytic hyperplasia Pneumocytic hyperplasia is an hyperplasia of pneumocytes lining pulmonary alveoli.
Types
*Pulmonary atypical adenomatous hyperplasia Atypical adenomatous hyperplasia is a subtype of pneumocytic hyperplasia in the lung. It can be a precursor les ...
References
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External links
Microscopical imagesMicroscopical imagesMicroscopical images
Pulmonary lesion